研究方向

1.药物化学，多肽及手性药物药理学

2.合理药物设计、合成与生物活性研究

3.多肽和小分子创新药物研发及临床前药物生理活性和构效关系研究

4.分子模拟，计算机辅助小分子及多肽药物设计

科研基金

1.主持国家自然基金青年科学基金项目, No. 21402076

2.参与多项国家自然基金重点项目及面上项目

3.主持并参与多项校级基金项目

科研成果

1.Xin Liu1, Yuan Wang1, Yanhong Xing1, Jing Yu, Hong Ji, Ming Kai, Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, and Rui Wang. Design, Synthesis, and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent μ-Opioid Agonists.Journal of Medicinal Chemistry,2013, 56, 3102-3114.

2.Xin Liu, Long Zhao, Yuan Wang, Lingyun Mou, Junxian Yang, Yixin Zhang, Dan Wang, Rui Wang.Design, synthesis, and evaluation of new endomorphin analogs withenhanced central antinociception after peripheral administration.Bioorganic & Medicinal Chemistry Letters. 2015, 25:5393- 5397.

3.Xin Liu, Long Zhao, Yuan Wang, Jingjing Zhou, Dan Wang, Yixin Zhang, Xianghui Zhang, Zhaojuan Wang, Dongxu Yang, Lingyun Mou, and Rui Wang.MEL-N16: A Series of Novel Endomorphin Analogs with Good Analgesic Activity and a Favorable Side Effect Profile.ACS Chem. Neurosci.,DOI:10.1021/acschemneuro.7b00097

4.Yuan Wang1, Yanhong Xing1, Xin Liu1, Hong Ji, Ming Kai, Zongyao Chen, Jing Yu, Depeng Zhao, and Rui Wang. A New Class of Highly Potent and Selective Endomorphin-1 Analogues Containing α-Methylene-β-aminopropanoic Acids (Map).Journal of Medicinal Chemistry, 2012, 55, 6224-6236.

5.Yuan Wang, Xin Liu, Dan Wang, Junxian Yang, Long Zhao, Jing Yu, Rui Wang*. Endomorphin-1 analogues (MELs) penetrate the bloode brain barrier and exhibit good analgesic effects with minimal side effects.Neuropharmacology，2015, 97, 312-321.

6.Yuan Wang, Junxian Yang, Xin Liu, Long Zhao, Dongxu Yang, Jingjing Zhou,Dan Wang, Lingyun Mou and Rui Wang. Endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration.Organic & Biomolecular Chemistry, 2017, 15, 4951–4955.

7.Yuan Wang, Jingjing Zhou, Xin Liu, Long Zhao, Zhaojuan Wang, Xianghui Zhang, Kezhou Wang,Linqing Wang, Rui Wang. Structure-constrained endomorphin analogs display differential antinociceptive mechanisms in mice after spinal administration.Peptides. 2017, 91, 40–48.

8.已授权国家发明专利专利号：ZL 201110455811.7 申请人：王锐，王媛，赵德鹏，刘鑫，邢燕红

9.已授权国家发明专利专利号：ZL 201210426909.4 申请人：王锐，刘鑫，王媛，邢燕红，赵德鹏

10.申请国家发明专利专利申请号：201510180151.4 申请人：王锐，刘鑫，王媛，王丹

11.申请国家发明专利专利申请号：201710067056.2申请人：王锐，王媛，刘鑫，赵龙